- Center for Advanced Infrastructure Technology
- Center for Applied Electromagnetic Systems Research
- Center for Archaeological Research
- Center for Biodiversity and Conservation Research
- Center for Community and Earthquake Preparedness
- Center for Economic Science and Economic Education
- Center for Research Evaluation
- Center for Excellence in Literacy Instruction
- Center for Excellence in Teaching and Learning
- Center for Graphene Research and Innovation
- Center for Health Behavior Research
- Center of Innovation and Entrepreneurship
- Center for Intelligence and Security Studies
- Center for Manufacturing Excellence
- Center for Mathematics and Science Education
- Center for Pharmaceutical Marketing and Management
- Center for Population Studies
- Center for Speech and Hearing Research
- Center for the Study of Southern Culture
- Center for Water and Wetland Resources
- Center for Wireless Communications
- Clinical Disaster Research Center
- FDA Center of Excellence on Botanical Dietary Supplement Research
- Graduate Center for the Study of Early Learning
- INDO-US Joint Center for Research in Indian Systems of Medicine
- Jackson Heart Study Vanguard Center at Oxford
- Jamie Whitten National Center for Physical Acoustics
- Magazine Innovation Center
- National Center for Computational Hydroscience and Engineering
- National Center for Natural Products Research
- National Center for Remote Sensing, Air and Space Law
- National Sea Grant Law Center
- Overby Center for Southern Journalism and Politics
- Pii Center for Pharmaceutical Technology
- Public Policy Research Center
- Sarah Isom Center for Women and Gender Studies
- Sino-U.S. Traditional Chinese Medicines Research Center
- University of Mississippi Geoinformatics Center